ABSTRACT
Multidrug resistance is one of the main causes of chemotherapy failure. In the past few decades, the development of nanotechnology has brought great hopes for the treatment of malignant tumors. Nanodrug delivery system effectively delivers the drug by endocytosis to avoid the drug being pumped out of the P-glycoprotein efflux pump, increasing the accumulation of the drug at the tumor site and reducing the toxicity of chemotherapeutic agents. Photothermal therapy uses the near-infrared laser for thermal ablation of tumors. The conversion of near-infrared light into high heat kills tumors, which is a new strategy for treating tumors. The use of nano-drug delivery system and photothermal therapy to overcome the multidrug resistance of tumors has incomparable advantages over traditional treatment. This paper reviewed the mechanism of multidrug resistance, the principle of reversal, the application of nano-drug delivery system and photothermal therapy in the reversal of multidrug resistance, the existing problems and prospects, in order to provide a new idea for reversing drug resistance.
ABSTRACT
Raman spectroscopy is amplified by surface-enhanced Raman scattering nanoparticles(SERS-NPs),and Raman signal can be enhanced by SERS-NPs,which can achieve high-resolution imaging of tumors.Meanwhile,SERS-NPs have high molecular specificity and sensitivity,showing a good prospect of tumor diagnosis and treatment.The advantages of SERS-NPs and its application in tumor diagnosis and treatment,and related experimental studies are reviewed in this article.